16p13.11 copy number variants (CNVs) are associated with numerous neurodevelopmental and intellectual disability disorders (IDDs) including epilepsy, schizophrenia, autism and psychosis. We utilize induced pluripotent stem cells (iPSCs) derived from patients with various 16p13.11 mutations to examine the effects novel gene mutations on the morphology, gene expression, and function of derived neurons. Additionally, we continue to optimize protocols for the generation of GABAergic neurons from patient-derived iPSCs that will be used to investigate the role of Tuberous Sclerosis (TSC) mutations on inhibitory interneurons. Our overall goal is to better understand the gene expression and morphological changes that occur in patient-derived neurons in an effort to improve patient-specific treatment options.